Iron In Brain Diseases

Post by ironjustice
Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's
disease, and amyotrophic lateral sclerosis.
Adv Pharmacol Sci. 2011;2011:378278. Epub 2011 Oct 12.
Oshiro S, Morioka MS, Kikuchi M.
Division of Cell Biology, Department of Health Science, Graduate
School of Sports and Health Science, Daito Bunka University, 560
Iwadono, Higashi-Matsuyama, Saitama 355-8501, Japan.
Abstract
Dysregulation of iron metabolism has been observed in patients with
neurodegenerative diseases (NDs).
Utilization of several importers and exporters for iron transport in
brain cells helps maintain iron homeostasis. Dysregulation of iron
homeostasis leads to the production of neurotoxic substances and
reactive oxygen species, resulting in iron-induced oxidative stress.
In Alzheimer's disease (AD) and Parkinson's disease (PD),
circumstantial evidence has shown that dysregulation of brain iron
homeostasis leads to abnormal iron accumulation.
Several genetic studies have revealed mutations in genes associated
with increased iron uptake, increased oxidative stress, and an altered
inflammatory response in amyotrophic lateral sclerosis (ALS).
Here, we review the recent findings on brain iron metabolism in common
NDs, such as AD, PD, and ALS.
We also summarize the conventional and novel types of iron chelators,
which can successfully decrease excess iron accumulation in brain
lesions.
For example, iron-chelating drugs have neuroprotective effects,
preventing neural apoptosis, and activate cellular protective pathways
against oxidative stress.
Glial cells also protect neurons by secreting antioxidants and
antiapoptotic substances.
These new findings of experimental and clinical studies may provide a
scientific foundation for advances in drug development for NDs.
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Nope!

Existential Angst

2011-10-22 18:19:42 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.

The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?

Even today iron-free supplements are a little scarce. Costco's Mature Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

John H. Gohde

2011-10-22 23:24:52 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!

Existential Angst

2011-10-23 05:43:16 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================

So how are those 50# of lost fat in 12 weeks doing?

--
EA

John H. Gohde

2011-10-24 04:33:24 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps.html

Existential Angst

2011-10-24 15:10:30 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps.html

==========================================================

Epigenetics is fine and good, but you still have not eliminated that 50# fat
loss bullshit.
http://naturalhealthperspective.com/exercise/losing-fat-without-dieting.html

You do a little better with the Shin Ohtake guy and his 6 worst things in
exercise
http://www.maxworkouts.com/?gclid=CNeRgcXLgawCFQ475QodI0v3Og

but he still overstates the whole fatburning bullshit, and still manages to
pollute good points with bullshit.

--
EA

John H. Gohde

2011-10-24 16:41:27 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved down our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps...
==========================================================
Epigenetics is fine and good, but you still have not eliminated that 50# fat
loss bullshit.http://naturalhealthperspective.com/exercise/losing-fat-without-dieti...
You do a little better with the Shin Ohtake guy and his 6 worst things in
exercisehttp://www.maxworkouts.com/?gclid=CNeRgcXLgawCFQ475QodI0v3Og
but he still overstates the whole fatburning bullshit, and still manages to
pollute good points with bullshit.
--
EA

Existential Angst

2011-10-24 20:36:36 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved
down
our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps...
==========================================================
Epigenetics is fine and good, but you still have not eliminated that 50# fat
loss
bullshit.http://naturalhealthperspective.com/exercise/losing-fat-without-dieti...
You do a little better with the Shin Ohtake guy and his 6 worst things in
exercisehttp://www.maxworkouts.com/?gclid=CNeRgcXLgawCFQ475QodI0v3Og
but he still overstates the whole fatburning bullshit, and still manages to
pollute good points with bullshit.
--
EA

Actually, you need to read more closely. :(

I asked the question: "Could any ordianary person starting from
scratch lose up to 50 pounds of fat, and beautifully reshape their
body, at the end of just 12 weeks (or 3 months) by a combination of
bodybuilding and aerobic exercise without dieting?"

Ego, it was a question rather than a statement of fact.

Then I said watch the Body of Work video of the "The 1997 Physique-
Transformation Challenge" or read the Fit for Life book to find out
the answer.

Furthermore, I have Facebook comments on my Web site.

So, what exactly needs to be corrected? Nothing, I presume. :)
=========================================================

Well, maybe your disingenuous marketing needs to be corrected, then.

Do you really want people to buy a book to find out they CANNOT lose 50# of
fat in 12 wks??
Thus, the inference is, you CAN lose 50# of fat in 12 wks, so the issue is
not yes or no, but HOW....

So tell us, just HOW do you lose 50# of fat in 12 wks?

Oh, and by the way, yer boi Shin Ohtake (the other book you shill for)
DISAGREES with bodybuilding and aerobics as a fitness/weightloss tool, and
says so in his 6 worst errors list that you link to.

You should pick ONE story and stick with it.

--
EA

John H. Gohde

2011-10-24 23:10:24 UTC

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved
down
our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps...
==========================================================
Epigenetics is fine and good, but you still have not eliminated that 50# fat
loss
bullshit.http://naturalhealthperspective.com/exercise/losing-fat-without-dieti...
You do a little better with the Shin Ohtake guy and his 6 worst things in
exercisehttp://www.maxworkouts.com/?gclid=CNeRgcXLgawCFQ475QodI0v3Og
but he still overstates the whole fatburning bullshit, and still manages to
pollute good points with bullshit.
--
EA

Actually, you need to read more closely. :(
I asked the question: "Could any ordianary person starting from
scratch lose up to 50 pounds of fat, and beautifully reshape their
body, at the end of just 12 weeks (or 3 months) by a combination of
bodybuilding and aerobic exercise without dieting?"
Ego, it was a question rather than a statement of fact.
Then I said watch the Body of Work video of the "The 1997 Physique-
Transformation Challenge" or read the Fit for Life book to find out
the answer.
Furthermore, I have Facebook comments on my Web site.
So, what exactly needs to be corrected? Nothing, I presume. :)
=========================================================
Well, maybe your disingenuous marketing needs to be corrected, then.
Do you really want people to buy a book to find out they CANNOT lose 50# of
fat in 12 wks??
Thus, the inference is, you CAN lose 50# of fat in 12 wks, so the issue is
not yes or no, but HOW....
So tell us, just HOW do you lose 50# of fat in 12 wks?
Oh, and by the way, yer boi Shin Ohtake (the other book you shill for)
DISAGREES with bodybuilding and aerobics as a fitness/weightloss tool, and
says so in his 6 worst errors list that you link to.
You should pick ONE story and stick with it.
--
EA

Videos do NOT lie! Watch the video. Do NOT buy it, see if I care.

In fact, I was originally selling it by way of Amazon.com. Now, I am
NOT sell it at all. Nor, has that author / company ever advertised on
my page.

I am NOT making a penny off the video or the book. Now, if you could
ONLY comprehend exactly what you are look at!!!

Existential Angst

2011-10-25 01:11:28 UTC

Post by ironjustice
Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's
disease, and amyotrophic lateral sclerosis.
Adv Pharmacol Sci. 2011;2011:378278. Epub 2011 Oct 12.
Oshiro S, Morioka MS, Kikuchi M.
Division of Cell Biology, Department of Health Science, Graduate
School of Sports and Health Science, Daito Bunka University, 560
Iwadono, Higashi-Matsuyama, Saitama 355-8501, Japan.
Abstract
Dysregulation of iron metabolism has been observed in patients with
neurodegenerative diseases (NDs).
Utilization of several importers and exporters for iron transport in
brain cells helps maintain iron homeostasis. Dysregulation of iron
homeostasis leads to the production of neurotoxic substances and
reactive oxygen species, resulting in iron-induced oxidative stress.
In Alzheimer's disease (AD) and Parkinson's disease (PD),
circumstantial evidence has shown that dysregulation of brain iron
homeostasis leads to abnormal iron accumulation.
Several genetic studies have revealed mutations in genes associated
with increased iron uptake, increased oxidative stress, and an altered
inflammatory response in amyotrophic lateral sclerosis (ALS).
Here, we review the recent findings on brain iron metabolism in common
NDs, such as AD, PD, and ALS.
We also summarize the conventional and novel types of iron chelators,
which can successfully decrease excess iron accumulation in brain
lesions.
For example, iron-chelating drugs have neuroprotective effects,
preventing neural apoptosis, and activate cellular protective pathways
against oxidative stress.
Glial cells also protect neurons by secreting antioxidants and
antiapoptotic substances.
These new findings of experimental and clinical studies may
provide
a
scientific foundation for advances in drug development for NDs.

It's pretty safe to assume that if Fe can deposit/adversely affect obvious
tissue, like heart, arterial, etc, that it can also adversely affect subtler
tissues, organs, etc.
The, uh, irony is, how long "One a Days WITH IRON" were, uh, shoved
down
our
throats, for effing SCORES of years, like, from 1950 thru 1990.
Another good FDA/NIH show, eh?
Even today iron-free supplements are a little scarce. Costco's Mature
Multi
is iron-free.
--
EA

Post by ironjustice
PMID:22013437
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Then you, also, have to learn to deal with ironjustice posting
exclusively about iron for the last decade!!!
===========================================
So how are those 50# of lost fat in 12 weeks doing?
--
EA

http://naturalhealthperspective.com/home/epigenetics-lifestyle-trumps...
==========================================================
Epigenetics is fine and good, but you still have not eliminated that 50# fat
loss
bullshit.http://naturalhealthperspective.com/exercise/losing-fat-without-dieti...
You do a little better with the Shin Ohtake guy and his 6 worst things in
exercisehttp://www.maxworkouts.com/?gclid=CNeRgcXLgawCFQ475QodI0v3Og
but he still overstates the whole fatburning bullshit, and still manages to
pollute good points with bullshit.
--
EA

Actually, you need to read more closely. :(
I asked the question: "Could any ordianary person starting from
scratch lose up to 50 pounds of fat, and beautifully reshape their
body, at the end of just 12 weeks (or 3 months) by a combination of
bodybuilding and aerobic exercise without dieting?"
Ego, it was a question rather than a statement of fact.
Then I said watch the Body of Work video of the "The 1997 Physique-
Transformation Challenge" or read the Fit for Life book to find out
the answer.
Furthermore, I have Facebook comments on my Web site.
So, what exactly needs to be corrected? Nothing, I presume. :)
=========================================================
Well, maybe your disingenuous marketing needs to be corrected, then.
Do you really want people to buy a book to find out they CANNOT lose 50# of
fat in 12 wks??
Thus, the inference is, you CAN lose 50# of fat in 12 wks, so the issue is
not yes or no, but HOW....
So tell us, just HOW do you lose 50# of fat in 12 wks?
Oh, and by the way, yer boi Shin Ohtake (the other book you shill for)
DISAGREES with bodybuilding and aerobics as a fitness/weightloss tool, and
says so in his 6 worst errors list that you link to.
You should pick ONE story and stick with it.
--
EA

Videos do NOT lie! Watch the video. Do NOT buy it, see if I care.
======================================================

They DON'T???????????????
Wow, I just lerntid sumpn!!

Does that video show/explain how to burn 15,000 cals a week?
Hmmmmm.... lessee, oh, I ALREADY figgered it out -- run 150 miles a
week!!!

Or eat NOTHING all week, for 12 solid weeks and then jog 10 miles each
week....
OK, I got it now....
--
EA

In fact, I was originally selling it by way of Amazon.com. Now, I am
NOT sell it at all. Nor, has that author / company ever advertised on
my page.

I am NOT making a penny off the video or the book. Now, if you could
ONLY comprehend exactly what you are look at!!!

John H. Gohde

2011-10-26 13:15:20 UTC

With all due respect, when YOUR theory does NOT agree with reality
then in the interest of science you are REQUIRED

John H. Gohde

2011-10-26 13:20:06 UTC

Existential Angst

2011-10-26 16:30:59 UTC

When YOUR theory does NOT correspond to reality then in the interest
of science YOU are REQUIRED to change YOUR theory.

The video proves YOU wrong. YOUR theory is operating in the vacuum of
non-reality. Now, it is up to YOU to fix it.

You have my condolences. :)
===================================================

Actually, the onus is on YOU.

Moi did not invent the equivalence between calorie burn and fat loss, which
is 3600 cals for each lb of fat.
Dats Nutrition 101, Weight Loss 101.

Since YOU (and this video) are claiming that you don't need to burn 15,000
cals a week to burn 4+ lbs of fat a week, YOU need to tell us what new
scientific principle applies.

Enlighten us, please.... or is this a Scientology-type deal, where you have
to pay to play?

--
EA

John H. Gohde

2011-10-26 23:11:47 UTC