Iron In Alzheimers

[ironjustice]

"Early event in AD pathology"

Modest Amyloid Deposition is Associated with Iron Dysregulation,
Microglial Activation, and Oxidative Stress.
J Alzheimers Dis 2011 Oct 4.
Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch
MA

There is a well-established literature indicating a relationship
between iron in brain tissue and Alzheimer's disease (AD).
More recently, it has become clear that AD is associated with
neuroinflammatory and oxidative changes which probably result from
microglial activation.
In this study, we investigated the correlative changes in microglial
activation, oxidative stress, and iron dysregulation in a mouse model
of AD which exhibits early-stage amyloid deposition.
Microfocus X-ray absorption spectroscopy analysis of intact brain
tissue sections prepared from AβPP/PS1 transgenic mice revealed the
presence of magnetite, a mixed-valence iron oxide, and local
elevations in iron levels in tissue associated with amyloid-β-
containing plaques.
The evidence indicates that the expression of markers of microglial
activation, CD11b and CD68, and astrocytic activation, GFAP, were
increased, and were histochemically determined to be adjacent to
amyloid-β-containing plaques.
These findings support the contention that, in addition to glial
activation and oxidative stress, iron dysregulation is an early event
in AD pathology.

Journal of Alzheimer's disease : JAD [J Alzheimers Dis]


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[Bohgosity BumaskiL]

If anything causes iron dysregulation, it iz probably Manganese, because
it iz in the same group, it is not magnetic, it supports a higher
oxidation state than Iron (permanganate), and it is needed in such small
amounts (micrograms) that you are more prone to getting too much than
too little. For example, it iz not part of Jamison supplements. Chromium
iz in the same class. It iz probably essential, and because of stainless
steel cooking hardware, you are prone to getting too much.

[Zrupfter]

Post by Bohgosity BumaskiL
If anything causes iron dysregulation, it iz probably Manganese, because
it iz in the same group, it is not magnetic, it supports a higher
oxidation state than Iron (permanganate), and it is needed in such small
amounts (micrograms) that you are more prone to getting too much than
too little.

The amount of manganese stored in the liver is closely related to estrogen
metabolism in both, males and females, so estrogen receptor-positive
malignancies (some breast or prostate cancers) are always reflected in
elevated manganese levels.
The same applies to specific lifestyles where an increased use of alcohol,
Tylenol, statin, or proton pump inhibitors, etc., will increase manganese
retention ( http://www.acu-cell.com/femn.html#liver ).

It is true that iron and manganese are associated, however requirements
of Mn are in the mg, not mcg range, and below-normal levels are found as
often as excessive levels, causing a wide range of medical symptoms that
include menstrual problems, PMS, hypoglycemia, and interestingly, being
prone to dislocating (knee) joints, among others.
In fact, some patients have to supplement manganese in the 25-50+mg
a day range, to maintain adequate levels. Regardless, iron or manganese
levels have little or nothing to do with Alzheimer's disease.

Post by Bohgosity BumaskiL
For example, it iz not part of Jamison supplements. Chromium
iz in the same class. It iz probably essential, and because of stainless
steel cooking hardware, you are prone to getting too much.

While the body is usually able to maintain what appears to be adequate
chromium levels, pseudodeficiencies of chromium are extremely common
as a result of excessive Cr antagonist activity, particularly with copper,
sometimes potassium, but especially as a result of dietary addictions to
simple sugars. While higher chromium levels are sometimes found in
cultures who consume a lot of shellfish, on average, lower chromium
levels in patients outnumber higher levels by a huge margin.

[Bohgosity BumaskiL]

Ash of [[Hamster]] is a vector of encephalopathy. That eliminates
protein or [[DNA|D.N.A.]] as a vector, and allows [[manganism]] as a
model of disease.
(see pub med "scrapie heat resistance")
http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10716712

This agrees with Purdey's epidemiology, where encephalopathy is
rampant among inhabitants of a Manganese mining operation.
http://books.google.ca/books?id=JpW_UmvGfoEC&pg=PA131&lpg=PA131&dq=manganese+mining+purdey&source=bl&ots=u5jZWwckSw&sig=chZfMgejK0GvjGDQ1KoMkKbXpoI&hl=en&sa=X&ei=xUxTT7DjG4Xu0gH_yeT_DQ&ved=0CCYQ6AEwAQ#v=onepage&q=manganese%20mining%20purdey&f=false|title=Animal
Pharm}}

It also agrees with research that shows Manganese makes a protein
into a polymer, which is therefore protease resistant.
http://www.pnas.org/cgi/pmidlookup?view=long&pmid=10716712

Post by Zrupfter

Post by Bohgosity BumaskiL
If anything causes iron dysregulation, it iz probably Manganese, because
it iz in the same group, it is not magnetic, it supports a higher
oxidation state than Iron (permanganate), and it is needed in such small
amounts (micrograms) that you are more prone to getting too much than
too little.

The amount of manganese stored in the liver is closely related to estrogen
metabolism in both, males and females, so estrogen receptor-positive
malignancies (some breast or prostate cancers) are always reflected in
elevated manganese levels.
The same applies to specific lifestyles where an increased use of alcohol,
Tylenol, statin, or proton pump inhibitors, etc., will increase manganese
retention ( http://www.acu-cell.com/femn.html#liver ).
It is true that iron and manganese are associated, however requirements
of Mn are in the mg, not mcg range, and below-normal levels are found as
often as excessive levels, causing a wide range of medical symptoms that
include menstrual problems, PMS, hypoglycemia, and interestingly, being
prone to dislocating (knee) joints, among others.
In fact, some patients have to supplement manganese in the 25-50+mg
a day range, to maintain adequate levels.
Regardless, iron or manganese
levels have little or nothing to do with Alzheimer's disease.

Cow pie.

Post by Zrupfter

Post by Bohgosity BumaskiL
For example, it iz not part of Jamison supplements. Chromium
iz in the same class. It iz probably essential, and because of stainless
steel cooking hardware, you are prone to getting too much.

While the body is usually able to maintain what appears to be adequate
chromium levels, pseudodeficiencies of chromium are extremely common
as a result of excessive Cr antagonist activity, particularly with copper,
sometimes potassium, but especially as a result of dietary addictions to
simple sugars. While higher chromium levels are sometimes found in
cultures who consume a lot of shellfish, on average, lower chromium
levels in patients outnumber higher levels by a huge margin.

[Bohgosity BumaskiL]

Post by Bohgosity BumaskiL
It also agrees with research that shows Manganese makes a protein
into a polymer, which is therefore protease resistant.

(my link was wrong [a repeat]). This iz what I meant:
http://www.ncbi.nlm.nih.gov/pubmed/22007749