AZD05030 Restores Memory and Synapse Loss in Alzheimer Mice

[Robert Miles]

AZD05030 Restores Memory and Synapse Loss in Alzheimer Mice
http://scitechdaily.com/azd05030-restores-memory-and-synapse-loss-in-alzheimer-mice/

Works in mice. However, whether it will works in humans depends on how
much like human Alzheimer's the mouse model of Alzheimer's is.

[Mark Thorson]

Post by Robert Miles
AZD05030 Restores Memory and Synapse Loss in Alzheimer Mice
http://scitechdaily.com/azd05030-restores-memory-and-synapse-loss-in-alzheimer-mice/

It's AZD0530. The article is mistaken.

Post by Robert Miles
Works in mice. However, whether it will works in humans depends on how
much like human Alzheimer's the mouse model of Alzheimer's is.

Not much like humans at all. They express
amyloid beta at vastly higher levels than
ever seen in any human brain.

In an initial trial, no benefit was seen.

http://alzres.com/content/pdf/s13195-015-0119-0.pdf

But another trial is underway. Maybe it
will show a benefit this time. It's
well-tolerated, so bumping up the dose
seems in order. Until you see toxicity,
no reason not to crank it up. (That one
case of possible toxicity, well who knows?
Maybe that guy ate a bad peanut or
something.)