It IS Iron

[ironjustice]

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.

Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-κB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.

PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[Marc Bissonnette]

ironjustice <***@hotmail.com> jumped out of the airlock. These
were their final words before their head exploded: news:527dd581-fb96-

Post by ironjustice
Towards a unifying, systems biology understanding of large-scale

[snip]

http://www.cbc.ca/consumer/story/2010/10/14/chelation-therapy-fda.html

FDA bans misleading chelation 'cures'
Last Updated: Thursday, October 14, 2010 | 7:04 PM ET
The Associated Press


Eight companies were warned Thursday to stop marketing chelation "miracle
cures" that claim to treat everything from autism to Parkinson's disease
by flushing toxic metals from the body, the U.S. Food and Drug
Administration said.

Regulators said the products, sold over the internet, can cause
dehydration, kidney failure and death.

Known as chelation therapies, the products have been used for decades,
although medical societies and government experts say there is no
evidence they cure diseases.

The only FDA-approved chelation therapies are used to treat lead and
mercury poisoning.

"These products are dangerously misleading because they are targeted to
patients with serious conditions and limited treatment options," said
FDA's Deborah Autor, director of compliance in the agency's Center for
Drug Evaluation and Research.

"The FDA must take a firm stand against companies who prey on the
vulnerability of patients seeking hope and relief."

The FDA said it has seen an uptick in the number of chelation products
sold over the internet.

The companies cited by the agency include World Health Products of
Draper, Utah, Cardio Renew of Apple Valley, Minn., and Hormonal Health of
San Bernardino, Calif.

The warning letters call on each company to immediately stop marketing
and selling their products or face legal action.

Their products come in a variety of forms, including sprays, capsules and
drops.

FDA officials said at least one death - involving a child with autism -
has been reported with a chelation product. The injectable treatment
linked to the death was not among the products targeted by Thursday's
action.

The agency noted that side-effects of such unproven remedies are often
not reported.

[Michael B]

Towards the unifying theory, I direct attention to the
use of Naltrexone for the endorphin excess of autism,
as well as low dose Naltrexone to help the body to
recognize what's supposed to be there, what's not,
so that necrosis factor doesn't come into play against
the host, or DOES get delivered to cancers that would
have otherwise slipped past.
And I invite folks to read some of the anecdotal evidence
regarding the stabilization of Alzheimers, and the
documentation behind Ultra-low-dose Naltrexone for
the purpose of preventing the gradual ramping up of
narcotics for equivalent level of analgesia. (Oxytrex,
interesting, too bad never be likely to be approved).
Ya know, there are women with metastatic breast
cancer, people with pancreatic cancer...well, you get
the idea.
Oh, silly me. I almost forgot that Rusty doesn't want
me on one of 'his' threads.

Post by Marc Bissonnette
were their final words before their head exploded: news:527dd581-fb96-

Post by ironjustice
Towards a unifying, systems biology understanding of large-scale

[snip]
FDA bans misleading chelation 'cures'
FDA officials said at least one death - involving a child with autism -
has been reported with a chelation product. The injectable treatment
linked to the death was not among the products targeted by Thursday's
action.

[ironjustice]

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.

Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.


PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[Marc Bissonnette]

ironjustice <***@rock.com> jumped out of the airlock. These were
their final words before their head exploded: news:852392b3-0928-4e58-

Post by ironjustice
Towards a unifying, systems biology understanding of large-scale

[snip]

http://www.cbc.ca/consumer/story/2010/10/14/chelation-therapy-fda.html

FDA bans misleading chelation 'cures'
Last Updated: Thursday, October 14, 2010 | 7:04 PM ET
The Associated Press


Eight companies were warned Thursday to stop marketing chelation "miracle
cures" that claim to treat everything from autism to Parkinson's disease
by flushing toxic metals from the body, the U.S. Food and Drug
Administration said.

Regulators said the products, sold over the internet, can cause
dehydration, kidney failure and death.

Known as chelation therapies, the products have been used for decades,
although medical societies and government experts say there is no
evidence they cure diseases.

The only FDA-approved chelation therapies are used to treat lead and
mercury poisoning.

"These products are dangerously misleading because they are targeted to
patients with serious conditions and limited treatment options," said
FDA's Deborah Autor, director of compliance in the agency's Center for
Drug Evaluation and Research.

"The FDA must take a firm stand against companies who prey on the
vulnerability of patients seeking hope and relief."

The FDA said it has seen an uptick in the number of chelation products
sold over the internet.

The companies cited by the agency include World Health Products of
Draper, Utah, Cardio Renew of Apple Valley, Minn., and Hormonal Health of
San Bernardino, Calif.

The warning letters call on each company to immediately stop marketing
and selling their products or face legal action.

Their products come in a variety of forms, including sprays, capsules and
drops.

FDA officials said at least one death - involving a child with autism -
has been reported with a chelation product. The injectable treatment
linked to the death was not among the products targeted by Thursday's
action.

The agency noted that side-effects of such unproven remedies are often
not reported.

[ironjustice]

I'm pretty sure I told ALL shteating frenchies to fkff ..

I wonder what it is about frenchies that they don't bother to learn
English ?

Toooooo fkg .. stoooooopid ..

Giiiiit ..

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.

Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.


PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[CSM]

Iron is a necessary nutrient, and many people aren't getting enough.
Be sure to get plenty of iron, preferably in food. Red meat is a good
source, and provides other nutrition as well in reasonable amounts.
If you don't get enough iron in your food, be sure to take a
supplement. Your doctor can help you determine how much you need, and
whether you need a supplement.
Oh, and by the way, those chelation "cures" are not only useless for
curing anything but heavy metal poisoning, they're positively toxic.
People have died from them.
HTH

[Michael B]

Last year, a study group excreted high amounts
of lead and mercury after a zeolite protocol, but
it was likely ion exchange rather than the process
we know as chelation.

Post by CSM
Oh, and by the way, those chelation "cures" are not only useless for
curing anything but heavy metal poisoning, they're positively toxic.
People have died from them.
HTH

[Bohgosity BumaskiL]

Subject-Was: Re: It IS Iron that we all need

Manganese and Iron are in a common group on periodic
tables, so if extra Iron helps Alzheimer's patients, it
might be because of competition. Manganese is one of those
metals, like Chromium, that are essential, and yet we need
so little, that we do not need supplementation outside of
being tube fed.

A side-effect of Iron supplementation is heart disease,
so you can see that even with a mineral that is needed
in relatively large amounts (milligrams/day, about a
thousand times more than micrograms/day for Chromium
and Manganese), even for Iron, such a thing as too much
_is_.

To remind you of my question: Both CJD and Alz refer to
plaques in the brain, and at least one of them is protease
resistant, probably the spiral form and the sheet forms
of a protein that has become protease resistant: The
cylindrical form of affected protein is probably normal.
_______
http://ecn.ab.ca/~brewhaha/

[Bohgosity BumaskiL]

Jesus SAVES! Passes to Moses. Shoots. Mohammad gets the rebound. He
shoots on his own net, the butt-fucked moron!

[Marc Bissonnette]

ironjustice <***@rock.com> jumped out of the airlock. These were
their final words before their head exploded: news:f29324b9-6c23-4764-
8112-***@v19g2000yqa.googlegroups.com:

[snip drivel]

http://www.cbc.ca/consumer/story/2010/10/14/chelation-therapy-fda.html

FDA bans misleading chelation 'cures'
Last Updated: Thursday, October 14, 2010 | 7:04 PM ET
The Associated Press


Eight companies were warned Thursday to stop marketing chelation "miracle
cures" that claim to treat everything from autism to Parkinson's disease
by flushing toxic metals from the body, the U.S. Food and Drug
Administration said.

Regulators said the products, sold over the internet, can cause
dehydration, kidney failure and death.

Known as chelation therapies, the products have been used for decades,
although medical societies and government experts say there is no
evidence they cure diseases.

The only FDA-approved chelation therapies are used to treat lead and
mercury poisoning.

"These products are dangerously misleading because they are targeted to
patients with serious conditions and limited treatment options," said
FDA's Deborah Autor, director of compliance in the agency's Center for
Drug Evaluation and Research.

"The FDA must take a firm stand against companies who prey on the
vulnerability of patients seeking hope and relief."

The FDA said it has seen an uptick in the number of chelation products
sold over the internet.

The companies cited by the agency include World Health Products of
Draper, Utah, Cardio Renew of Apple Valley, Minn., and Hormonal Health of
San Bernardino, Calif.

The warning letters call on each company to immediately stop marketing
and selling their products or face legal action.

Their products come in a variety of forms, including sprays, capsules and
drops.

FDA officials said at least one death - involving a child with autism -
has been reported with a chelation product. The injectable treatment
linked to the death was not among the products targeted by Thursday's
action.

The agency noted that side-effects of such unproven remedies are often
not reported.

[ironjustice]

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.


Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.


PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[ironjustice]

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.

Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.


PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

[Hawaiian Wayne]

Post by ironjustice
Towards a unifying, systems biology understanding of large-scale
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.
PMID: 20967426
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
Man Is A Herbivore!http://tinyurl.com/a3cc3
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

Aloha Michael B.!

You had to go and encourage him....really...

Aloha For Now,
Hawaiian Wayne

[Michael B]

Naah. He's a lot more encouraged by his mommy
calling him up from the basement for supper.

Post by Hawaiian Wayne
Aloha Michael B.!
You had to go and encourage him....really...
Aloha For Now,
Hawaiian Wayne

[ironjustice]

Towards a unifying, systems biology understanding of large-scale
cellular death and destruction caused by poorly liganded iron:
Parkinson's, Huntington's, Alzheimer's, prions, bactericides,
chemical toxicology and others as examples.
Kell DB.
Arch Toxicol. 2010 Aug 17.
School of Chemistry and the Manchester Interdisciplinary Biocentre,
The University of Manchester, Manchester, M1 7DN, UK,
***@manchester.ac.uk.

Abstract
Exposure to a variety of toxins and/or infectious agents leads to
disease, degeneration and death, often characterised by circumstances
in which cells or tissues do not merely die and cease to function but
may be more or less entirely obliterated.
It is then legitimate to ask the question as to whether, despite the
many kinds of agent involved, there may be at least some unifying
mechanisms of such cell death and destruction.
I summarise the evidence that in a great many cases, one underlying
mechanism, providing major stresses of this type, entails continuing
and autocatalytic production (based on positive feedback mechanisms)
of hydroxyl radicals via Fenton chemistry involving poorly liganded
iron, leading to cell death via apoptosis (probably including via
pathways induced by changes in the NF-êB system).
While every pathway is in some sense connected to every other one,
I highlight the literature evidence suggesting that the degenerative
effects of many diseases and toxicological insults converge on iron
dysregulation.
This highlights specifically the role of iron metabolism, and the
detailed speciation of iron, in chemical and other toxicology, and
has significant implications for the use of iron chelating substances
(probably in partnership with appropriate anti-oxidants) as
nutritional
or therapeutic agents in inhibiting both the progression of these
mainly degenerative diseases and the sequelae of both chronic and
acute
toxin exposure.
The complexity of biochemical networks, especially those involving
autocatalytic behaviour and positive feedbacks, means that multiple
interventions (e.g. of iron chelators plus antioxidants) are likely
to
prove most effective.
A variety of systems biology approaches, that I summarise, can
predict
both the mechanisms involved in these cell death pathways and the
optimal sites of action for nutritional or pharmacological
interventions.


PMID: 20967426


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk